The visiting Red Wings dominated rookie goaltender Malcolm Subban, Pavel Datsyuk had a goal and three assists, and Henrik Zetterberg scored twice to spoil the Bruins first preseason game at TD Garden.
Zetterberg scored once in each of the first two periods, then had an assist as Datsyuk capped Detroit's four-goal third period. Jimmy Howard played the first two periods and stopped 14 of 15 shots.
Jarome Iginla and Nick Johnson had goals for Boston. Subban, the Bruins' first-round pick (No. 24) in the 2012 NHL Draft, went all the way and stopped 20 shots.
"You can't fault him for anything tonight," defenseman Matt Bartkowski said. "It doesn't matter if it's his first game or his 50th, we left him out to dry."